5-Methyl-2-pyrrolidone → 1-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-5-methylpyrrolidin-2-one

HRID 2411697ノート

反応式

HRID 2411697 の反応式
[CH3:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1.Br[C:9]1[N:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH:29]4[CH2:31][CH2:30]4)=[CH:27][C:26]([CH:32]4[CH2:34][CH2:33]4)=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:11][CH:10]=1>>[CH:29]1([C:28]2[C:23]([N:20]3[CH2:19][CH2:18][N:17]([C:15]([C:12]4[CH:11]=[CH:10][C:9]([N:6]5[CH:2]([CH3:1])[CH2:3][CH2:4][C:5]5=[O:7])=[N:14][CH:13]=4)=[O:16])[CH2:22][CH2:21]3)=[N:24][CH:25]=[C:26]([CH:32]3[CH2:34][CH2:33]3)[CH:27]=2)[CH2:30][CH2:31]1

参加物

3

反応物 2

HCID 660555-Methyl-2-pyrrolidoneHCID 58484777(6-Bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone

生成物 1

HCID 712523091-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-5-methylpyrrolidin-2-one収率 2,987.4%

実験手順

Using 5-methylpyrrolidin-2-one (99 mg) and (6-bromopyridin-3-yl) [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (4.27 mg) described in Preparation Example 143 and by the reaction and treatment in the same manner as in Example 1, the title compound (133 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 143 and by the reaction and treatment in the same manner as in Example 1

出典と根拠

ORDレコード
ord-9f67d927b1124cbdbed913eec9df42b6
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…