2-Pyrrolidone → 1-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}pyrrolidin-2-one
反応式
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[CH:7]1([C:10]2[C:11]([N:19]3[CH2:24][CH2:23][N:22]([C:25]([C:27]4[CH:28]=[N:29][C:30](F)=[CH:31][C:32]=4[CH3:33])=[O:26])[CH2:21][CH2:20]3)=[N:12][CH:13]=[C:14]([CH:16]3[CH2:18][CH2:17]3)[CH:15]=2)[CH2:9][CH2:8]1>>[CH:7]1([C:10]2[C:11]([N:19]3[CH2:20][CH2:21][N:22]([C:25]([C:27]4[C:32]([CH3:33])=[CH:31][C:30]([N:1]5[CH2:5][CH2:4][CH2:3][C:2]5=[O:6])=[N:29][CH:28]=4)=[O:26])[CH2:23][CH2:24]3)=[N:12][CH:13]=[C:14]([CH:16]3[CH2:18][CH2:17]3)[CH:15]=2)[CH2:8][CH2:9]1参加物
3
実験手順
Using pyrrolidin-2-one (326 μL) and [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (400 mg) described in Preparation Example 174 and by the reaction and treatment in the same manner as in Example 323, the title compound (187 mg) was obtained.
後処理
- customdescribed in Preparation Example 174 and by the reaction and treatment in the same manner as in Example 323
出典と根拠
- ORDレコード
- ord-7773fb8d25254b649fb9c9e9e1be985f
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08816079B2
反応ノート
読み込み中…