4-((2-Oxopyrrolidin-1-yl)methyl)benzoic acid → HCID 71251923、化合物

HRID 2411728ノート

反応式

HRID 2411728 の反応式
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=1.[CH:17]1([C:20]2[CH:21]=[C:22]([CH3:32])[C:23]([N:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)=[N:24][CH:25]=2)[CH2:19][CH2:18]1>>[CH:17]1([C:20]2[CH:21]=[C:22]([CH3:32])[C:23]([N:26]3[CH2:27][CH2:28][N:29]([C:12]([C:11]4[CH:10]=[CH:9][C:8]([CH2:7][N:3]5[CH2:4][CH2:5][CH2:6][C:2]5=[O:1])=[CH:16][CH:15]=4)=[O:14])[CH2:30][CH2:31]3)=[N:24][CH:25]=2)[CH2:19][CH2:18]1

参加物

3

反応物 2

HCID 49622004-((2-Oxopyrrolidin-1-yl)methyl)benzoic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

生成物 1

HCID 71251923HCID 71251923、化合物収率 36.1%

実験手順

Using 4-(2-oxopyrrolidin-1-ylmethyl)benzoic acid (132 mg) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (156 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87, the title compound (91 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87

出典と根拠

ORDレコード
ord-c3b2397d86e049a7a308847c7023e841
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…