3-(4-Methoxybenzyl)-5-methylimidazolidine-2,4-dione → 1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-(4-methoxybenzyl)-5-methylimidazolidine-2,4-dione

HRID 2411799ノート

反応式

HRID 2411799 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:24][O:25][C:26]1[CH:40]=[CH:39][C:29]([CH2:30][N:31]2[C:35](=[O:36])[CH:34]([CH3:37])[NH:33][C:32]2=[O:38])=[CH:28][CH:27]=1>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:33]4[CH:34]([CH3:37])[C:35](=[O:36])[N:31]([CH2:30][C:29]5[CH:39]=[CH:40][C:26]([O:25][CH3:24])=[CH:27][CH:28]=5)[C:32]4=[O:38])=[CH:3][CH:4]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

参加物

3

反応物 2

HCID 683283563-(4-Methoxybenzyl)-5-methylimidazolidine-2,4-dioneHCID 71252046(4-Bromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

生成物 1

HCID 712525731-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-(4-methoxybenzyl)-5-methylimidazolidine-2,4-dione収率 86.5%

実験手順

Using (4-bromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 165 and 3-(4-methoxybenzyl)-5-methylimidazolidine-2,4-dione (141 mg) described in Preparation Example 51 and by the reaction and treatment in the same manner as in Example 1, the title compound (183 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 51 and by the reaction and treatment in the same manner as in Example 1

出典と根拠

ORDレコード
ord-5f30b1964f8c43a2a5c28d85cdaa3494
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…