1-(3,5-Dimethylpyridin-2-yl)piperazine → (1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-methylethyl)carbamic acid ethyl ester

HRID 2411831ノート

反応式

HRID 2411831 の反応式
[CH2:1]([O:3][C:4]([NH:6][C:7]([C:10]1[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=O)=[CH:12][CH:11]=1)([CH3:9])[CH3:8])=[O:5])[CH3:2].[CH3:20][C:21]1[C:22]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[N:23][CH:24]=[C:25]([CH3:27])[CH:26]=1>>[CH2:1]([O:3][C:4](=[O:5])[NH:6][C:7]([C:10]1[CH:11]=[CH:12][C:13]([C:14]([N:31]2[CH2:32][CH2:33][N:28]([C:22]3[C:21]([CH3:20])=[CH:26][C:25]([CH3:27])=[CH:24][N:23]=3)[CH2:29][CH2:30]2)=[O:16])=[CH:18][CH:19]=1)([CH3:8])[CH3:9])[CH3:2]

参加物

3

反応物 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252297Methyl 4-(1-ethoxycarbonylamino-1-methylethyl)benzoate

生成物 1

HCID 71252363(1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-methylethyl)carbamic acid ethyl ester収率 82.2%

実験手順

Using methyl 4-(1-ethoxycarbonylamino-1-methylethyl)benzoate (174 mg) described in Preparation Example 70 and 1-(3,5-dimethylpyridin-2-yl)piperazine (138 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (229 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

出典と根拠

ORDレコード
ord-721b5481c02346628812d8e69bb86807
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…