N,N'-Dimethylethylenediamine → 3-Benzyloxymethyl-1-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-5-methylimidazolidine-2,4-dione

反応式

CNCCNC.Br[C:8]1[CH:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH:29]4[CH2:31][CH2:30]4)=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:10]([F:32])[CH:9]=1.[CH2:33]([O:40][CH2:41][N:42]1[C:46](=[O:47])[CH:45]([CH3:48])[NH:44][C:43]1=[O:49])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>[Cu]I.O.O1CCOCC1>[CH2:33]([O:40][CH2:41][N:42]1[C:46](=[O:47])[CH:45]([CH3:48])[N:44]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([N:16]3[CH2:21][CH2:20][N:19]([C:22]4[C:27]([CH3:28])=[CH:26][C:25]([CH:29]5[CH2:31][CH2:30]5)=[CH:24][N:23]=4)[CH2:18][CH2:17]3)=[O:15])=[C:10]([F:32])[CH:9]=2)[C:43]1=[O:49])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1