Potassium Hydroxide → E-1-cinnamyl-2-fluoro-imidazole
反応式
Cl.[F:2][C:3]1[NH:4][CH:5]=[CH:6][N:7]=1.[OH-].[K+].[CH2:10](Br)/[CH:11]=[CH:12]/[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CC(C)=O>[CH2:10]([N:4]1[CH:5]=[CH:6][N:7]=[C:3]1[F:2])/[CH:11]=[CH:12]/[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1参加物
5
実験手順
2-Fluoroimidazole hydrochloride was added to a suspension of powdered KOH in acetone, stirred for 10 minutes, and E-cinnamyl bromide added. After stirring 1 hour, the mixture was worked up by extraction and chromatography to give E-1-cinnamyl-2-fluoro-imidazole, having the following n.m.r. in CDCl3 : 4.6 (d, 2H); 6.1-6.4 (d of t, 1H); 6.6 (d, 1H); 6.6-6.8 (m, 2H); 7.2-7.5 (m, 5H).
後処理
- stirringAfter stirring 1 hour
- extractionthe mixture was worked up by extraction and chromatography
出典と根拠
- ORDレコード
- ord-bca4cc9ebde1448ab07a897cc66b562a
- 出典データセット
- uspto-grants-1985_01
- 特許番号
- US04492692
反応ノート
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