Dimethyl Sulfoxide → Vinylbenzyl p-hydroxybenzoate

HRID 2412585

反応式

HRID 2412585 の反応式
[CH:1]([CH:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[CH2:2].[OH:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([O-:18])=[O:17])=[CH:14][CH:13]=1.[Na+].CS(C)=O>O>[OH:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([O:18][CH:3]([CH:1]=[CH2:2])[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:17])=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 679Dimethyl SulfoxideHCID 11768772Benzene, 1-(chloromethyl)-3(or 4)-ethenyl-HCID 16219477Sodium 4-hydroxybenzoate

生成物 1

HCID 20432038Vinylbenzyl p-hydroxybenzoate収率 92.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

71.5 g of vinylbenzyl chloride and 75.0 g of sodium p-hydroxybenzoate were added to 250 ml of dimethylsulfoxide and stirred and reacted at 40° C. for 4 days. Then 1,000 ml of water was added thereto, and the resulting mixture was extracted with 200 ml of ethyl acetate. After distilling off ethyl acetate, recrystallization of the residue from benzene-hexane mixture solvent yielded 110 g of vinylbenzyl p-hydroxybenzoate (m.p. 83°-85° C.).

後処理

  1. customreacted at 40° C. for 4 days
  2. extractionthe resulting mixture was extracted with 200 ml of ethyl acetate
  3. distillationAfter distilling off
  4. customethyl acetate, recrystallization of the residue from benzene-hexane mixture solvent

出典と根拠

ORDレコード
ord-739e1f7ac7e646cd82e3c8d4326df2ef
出典データセット
uspto-grants-1985_01
特許番号
US04493884

関連ノート

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