4-Fluorobenzenesulfonyl chloride → 4-fluoro-N-[4-(thiazol-2-yl)benzyl]benzenesulfonamide
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl.[S:13]1[CH:17]=[CH:16][N:15]=[C:14]1[C:18]1[CH:25]=[CH:24][C:21]([CH2:22][NH2:23])=[CH:20][CH:19]=1.Cl.C1(C2N=NC(CN)=CC=2)C=CC=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:23][CH2:22][C:21]2[CH:20]=[CH:19][C:18]([C:14]3[S:13][CH:17]=[CH:16][N:15]=3)=[CH:25][CH:24]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1参加物
4
実験手順
Reaction and post-treatment were carried out in the same manner as in Reference Example 2-(d) except for using 4-fluorobenzenesulfonyl chloride (278 mg, 1.42 mmol) in place of 3-pyridylsulfonyl chloride, and using 4-(thiazol-2-yl)benzylamine hydrochloride (364 mg, 1.38 mmol) obtained in Reference Example 4-(d) in place of (6-phenylpyridazin-3-ylmethyl)amine hydrochloride to afford the title compound (411 mg) as a slightly yellow solid. (Yield: 85%)