Cyanogen Bromide → HCID 13392479、化合物

HRID 2413111ノート

反応式

HRID 2413111 の反応式
[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9]([CH3:13])[CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[N:14]#CBr>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9]([C:13]#[N:14])[CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 10476Cyanogen BromideHCID 123981Benalfocin

生成物 1

HCID 13392479HCID 13392479、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

A stirred solution of 1.2 g. of 6-chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine in 30 ml. of toluene was treated at 50° by dropwise addition with a solution of 0.7 g. cyanogen bromide in 25 ml. of toluene. Following the addition, the mixture was stirred and heated at 50° for one hour. A stream of nitrogen was passed over the surface of the solution during the reaction. The mixture was cooled, filtered and the filtrate concentrated in vacuo to yield 6-chloro-3-cyano-2,3,4,5-tetrahydro-1H-3-benzazepine melting at 81°-82° from hexane-ether solution.

後処理

  1. additionthe addition
  2. temperatureheated at 50° for one hour
  3. customA stream of nitrogen was passed over the surface of the solution during the reaction
  4. temperatureThe mixture was cooled
  5. filtrationfiltered
  6. concentrationthe filtrate concentrated in vacuo

出典と根拠

ORDレコード
ord-a4c454f5a33a4e32af9e5bf54f8064ad
出典データセット
uspto-grants-1985_01
特許番号
US04496558

反応ノート

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