(Chloromethyl)(4-chlorophenyl)dimethylsilane → (4-Chlorophenyl)dimethyl(1H-imidazol-1-ylmethyl)silane

HRID 2413307

反応式

HRID 2413307 の反応式
Cl[CH2:2][Si:3]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)([CH3:5])[CH3:4].[Na].[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>CN(C)C=O.O>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([Si:3]([CH3:5])([CH3:4])[CH2:2][N:14]2[CH:18]=[CH:17][N:16]=[CH:15]2)=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 2733089(Chloromethyl)(4-chlorophenyl)dimethylsilaneHCID 57373095Imidazole sodium

生成物 1

HCID 20430362(4-Chlorophenyl)dimethyl(1H-imidazol-1-ylmethyl)silane収率 81%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2.2 g (0.010 mol) of chloromethyl(4-chlorophenyl)dimethylsilane and 1.1 g (0.012 mol) of imidazole sodium salt in 5 ml of dimethylformamide was stirred at 80°-90° for 2 hours, cooled, diluted with water, and extracted with ether. The ether solution was washed with water and brine, dried over magnesium sulfate, and evaporated to leave 2.0 g (81%) of the title compound as a yellow liquid: nD20 1.5472; ir (neat) 1560, 1495, 1480, 1375, 1250, 1105, 1080, 905, 830, 810, 740 cm-1 ; nmr (CDCl3) 0.3 (6H, s), 3.6 (2H, s), 6.6 (1H, broad s), 6.9 (1H, broad s), 7.1 (1H, broad s), 7.3 (4H, s).

後処理

  1. temperaturecooled
  2. extractionextracted with ether
  3. washThe ether solution was washed with water and brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-7f7f78be48114def9b364ce1bab25c3c
出典データセット
uspto-grants-1985_01
特許番号
US04496551

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