Triethylamine → N-(4-Bromophenyl)-N-methyl-3-methyl-2-butenamide

HRID 24135

反応式

HRID 24135 の反応式
[CH3:1][C:2]([CH3:7])=[CH:3][C:4](Cl)=[O:5].[Br:8][C:9]1[CH:16]=[CH:15][C:12]([NH:13][CH3:14])=[CH:11][CH:10]=1.C(N(CC)CC)C>ClCCl>[Br:8][C:9]1[CH:16]=[CH:15][C:12]([N:13]([CH3:14])[C:4](=[O:5])[CH:3]=[C:2]([CH3:7])[CH3:1])=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 1023943-Methyl-2-butenoyl chlorideHCID 2757052Benzenamine, 4-bromo-N-methyl-

生成物 1

HCID 22568913N-(4-Bromophenyl)-N-methyl-3-methyl-2-butenamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3,3-Dimethylacryloyl chloride (3 mL, 27 mmol) was added to a solution of 4-bromo-N-methyl-aniline (4.55 g, 25 mmol) in 150 mL of dichloromethane followed after 5 minutes by triethyl amine (5 mL, 33 mmol). After 2.5 h at ambient temperature, the reaction mixture was washed with water and the organic phase was dried over anhydrous sodium sulfate and evaporated in vacuo to afford the title product as a brown oil in quantitative yield.

後処理

  1. washthe reaction mixture was washed with water
  2. dry with materialthe organic phase was dried over anhydrous sodium sulfate
  3. customevaporated in vacuo

出典と根拠

ORDレコード
ord-90623539d9304fb8841d096e490d9518
出典データセット
uspto-grants-2005_02
特許番号
US06855512B2

関連ノート

読み込み中…