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N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline benzylester → N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline

HRID 2413731
ノート
印刷プレビュー

反応式

HRID 2413731 の反応式
C([O:8][C:9](=[O:34])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:33])[C@@H:16]1[CH2:20][CH2:19][CH2:18][N:17]1[C:21](=[O:32])[C@H:22]([CH3:31])[NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])C1C=CC=CC=1.[H][H]>CO.[C].[Pd]>[C:27]([O:26][C:24]([NH:23][C@H:22]([C:21]([N:17]1[CH2:18][CH2:19][CH2:20][C@H:16]1[C:15]([N:11]1[CH2:12][CH2:13][CH2:14][C@H:10]1[C:9]([OH:34])=[O:8])=[O:33])=[O:32])[CH3:31])=[O:25])([CH3:28])([CH3:29])[CH3:30]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 13389836N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline benzylesterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 22827655N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline収率 99.8%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline benzylester (5.0 g, 10.6 m mole) was dissolved in methanol (100 ml) and hydrogen gas was passed through the solution in the presence of the palladium carbon as a catalyst for 3 hours. The catalyst was removed by filtration and the solvent was distilled off under reduced pressure. Thus obtained residue was dissolved in water and the solution was freeze-dried to give N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline (4.04 g).

後処理

  1. customThe catalyst was removed by filtration
  2. distillationthe solvent was distilled off under reduced pressure
  3. dissolutionThus obtained residue was dissolved in water
  4. customthe solution was freeze-dried

出典と根拠

ORDレコード
ord-5f834158ad0144d7b17427348fa3791d
出典データセット
uspto-grants-1988_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04719200

反応ノート

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