Acetyl chloride → N-[(5-Acetyl-2-thienyl)methyl]acetamide

HRID 2413891ノート

反応式

HRID 2413891 の反応式
[C:1]([NH:4][CH2:5][C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2].[C:11](Cl)(=[O:13])[CH3:12].[Cl-].[Al+3].[Cl-].[Cl-]>ClC(Cl)C>[C:1]([NH:4][CH2:5][C:6]1[S:7][C:8]([C:11](=[O:13])[CH3:12])=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 30617N-[(thiophen-2-yl)methyl]acetamideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 7131592N-[(5-Acetyl-2-thienyl)methyl]acetamide

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

反応条件

温度
10 °C

実験手順

To a solution of 40 g of 2-acetylaminomethylthiophene and 30.3 g of acetylchloride in 600 ml of dichloroethane is added a small portion of 76.3 g of anhydrous aluminum chloride under cooling at 5°-10° C. After the mixture is stirred at 10° C. for 30 minutes and poured into ice-cold water, the precipitated crystals are collected by filtration to give 2-acetylaminomethyl-5-acetylthiophene, melting F- at 129°-130° C.

後処理

  1. temperatureunder cooling at 5°-10° C
  2. additionpoured into ice-cold water
  3. filtrationthe precipitated crystals are collected by filtration

出典と根拠

ORDレコード
ord-6a711cea372044ecb528741d3b543c97
出典データセット
uspto-grants-1988_01
特許番号
US04720493

反応ノート

読み込み中…