Thiourea → 5-(2-Amino-4-thiazolyl)-1,3-dihydro-2H-indol-2-one

HRID 2414110ノート

反応式

HRID 2414110 の反応式
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)=O.[NH2:15][C:16]([NH2:18])=[S:17]>CCO>[NH2:18][C:16]1[S:17][CH:2]=[C:3]([C:5]2[CH:6]=[C:7]3[C:11](=[CH:12][CH:13]=2)[NH:10][C:9](=[O:14])[CH2:8]3)[N:15]=1

参加物

4

反応物 2

HCID 2723790ThioureaHCID 220993095-(Bromoacetyl)-1,3-dihydro-2H-indol-2-one

生成物 1

HCID 26087615-(2-Amino-4-thiazolyl)-1,3-dihydro-2H-indol-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 5-(α-bromoacetyl)oxindole (5 g) and thiourea (1.67 g) in absolute EtOH (250 ml) is refluxed for 30 minutes. The reaction mixture is cooled to RT, filtered, and washed with absolute EtOH affording the desired product. The free base is converted to its methanesulfonate salt by the procedure previously described in Example 12, affording the desired product, M.P.=244°-246° C.

後処理

  1. filtrationfiltered
  2. washwashed with absolute EtOH affording the desired product

出典と根拠

ORDレコード
ord-3b586d910641479c91ccb9d565a2c5aa
出典データセット
uspto-grants-1988_01
特許番号
US04721721

反応ノート

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