関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,3-Diaminopyridine | HCID 9956 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Amino-5-bromonicotinic acid | HCID 737445 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-bromo-3-(1H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-ylamine | HCID 66869810 | — |
反応手順
50 mg (0.230 mmol) I) of 2-amino-5-bromonicotinic acid and 27.6 mg (0.253 mmol) of pyridine-2,3-diamine are added to 451.5 mg (5 mmol) of polyphosphoric acid, and the mixture is stirred at 160° C. for 4 days. The reaction mixture is cooled to room temperature, water is added, and the mixture is adjusted to pH 12 by means of 1N NaOH. The precipitate formed is filtered off with suction and dried, giving 5-bromo-3-(1H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-ylamine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08648201B2 |
|---|
| 出典データセット | uspto-grants-2014_02 |
|---|
| ORD ID | ord-725e8d02c86f429892222bd9e70741e6 |
|---|
| 出典メモ | uspto-grants-2014_02 |
|---|
