HCID 67937983、化合物 → HCID 18603873、化合物

HRID 2414177ノート

反応式

HRID 2414177 の反応式
[C:1]([NH:5][C:6]([C@H:8]1[CH2:13][N:12]([CH3:14])[C@@H:11]2[CH2:15][O:16][C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][C:18]=3[C:10]2=[CH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[O-]CC.[Na+]>[C:1]([NH:5][C:6]([C@H:8]1[CH2:13][N:12]([CH3:14])[C@H:11]2[CH2:15][O:16][C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][C:18]=3[C:10]2=[CH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 1

HCID 67937983HCID 67937983、化合物

生成物 1

HCID 18603873HCID 18603873、化合物

試薬・触媒・溶媒 1

HCID 2723922Sodium ethoxide溶媒

実験手順

A solution of 950 mg of cis-2-(N-t-butylcarbamoyl)-9-methoxy-4-methyl-2,3,4a,5-tetrahydro-4H-[1]-benzopyrano[3,4-b]pyridine in 50 ml of 0.1M ethanolic sodium ethoxide is heated at 70° for 15 minutes. After removal of the solvent in vacuo, the residue is chromatographed over 20 g of silica gel with ether/hexane 1:1 as the eluent to give trans-2-(N-t-butylcarbamoyl)-9-methoxy-4-methyl-2,3,4a,5-tetrahydro-4H-[1]-benzopyrano[3,4-b]pyridine crystallized as the hydrochloride salt, melting point 238°-240°.

後処理

  1. customAfter removal of the solvent in vacuo
  2. customthe residue is chromatographed over 20 g of silica gel with ether/hexane 1:1 as the eluent

出典と根拠

ORDレコード
ord-d6ebff068f4343cc93cf9b15f5fb3ee1
出典データセット
uspto-grants-1988_01
特許番号
US04721787

反応ノート

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