Triethylamine → 4-methylsulfonamido-N-[2-[(1-methylethyl)amino]ethyl]benzene sulfonamide

反応式

[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1)(=[O:4])=[O:3].[CH:16]([NH:19][CH2:20][CH2:21][NH2:22])([CH3:18])[CH3:17].C(N(CC)CC)C>C(Cl)Cl>[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([NH:22][CH2:21][CH2:20][NH:19][CH:16]([CH3:18])[CH3:17])(=[O:14])=[O:13])=[CH:8][CH:7]=1)(=[O:4])=[O:3]

参加物

実験手順

4-methylsulfonamidobenzenesulfonyl chloride (2.70 g) was added portionwise to a 0.01 mole portion of N-isopropylethylenediamine and triethylamine (0.01 mole) in methylene chloride (250 ml) to obtain a white solid which precipitated from the methylene chloride reaction mixture 2.62 g, m.r. 180°-182° C. This solid was washed well with methylene chloride, dissolved in isopropanol/HCl/methanol and the methanol boiled away. The product was precipitated and filtered to yield 1.65 g, m.r. 158°-160° C.(d).