Triethylamine → n-{3-Chloro-4-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]phenyl}-2-methylpropanamide

HRID 2414324

反応式

HRID 2414324 の反応式
[C:1](Cl)(=[O:5])[CH:2]([CH3:4])[CH3:3].[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][CH:17]([N:20]3[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[CH2:23][O:22][C:21]3=[O:30])[CH2:16][CH2:15]2)=[C:10]([Cl:31])[CH:9]=1.C(N(CC)CC)C>ClCCl>[Cl:31][C:10]1[CH:9]=[C:8]([NH:7][C:1](=[O:5])[CH:2]([CH3:4])[CH3:3])[CH:13]=[CH:12][C:11]=1[N:14]1[CH2:15][CH2:16][CH:17]([N:20]2[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[CH2:23][O:22][C:21]2=[O:30])[CH2:18][CH2:19]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 62325Isobutyryl chlorideHCID 226446801-[1-(4-Amino-2-chlorophenyl)piperidin-4-yl]-1,4-dihydro-2H-3,1-benzoxazin-2-one

生成物 1

HCID 22644591n-{3-Chloro-4-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]phenyl}-2-methylpropanamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Isobutyryl chloride (0.017 ml) was added to a stirred solution of the product from example 120 step (ii) (0.05 g) and triethylamine (0.07 ml) in dichloromethane (1 ml) at room temperature. After 2 h the mixture was partitioned between ethyl acetate and water, the organics separated, washed with water, dried, and evaporated under reduced pressure. Trituration with ether gave a solid, yield 0.048 g.

後処理

  1. customAfter 2 h the mixture was partitioned between ethyl acetate and water
  2. washthe organics separated, washed with water
  3. customdried
  4. customevaporated under reduced pressure
  5. customTrituration with ether gave a solid, yield 0.048 g

出典と根拠

ORDレコード
ord-99cb95e98b2640419c96e528e43f0fc9
出典データセット
uspto-grants-2004_11
特許番号
US06812226B2

関連ノート

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