6-chloro-N-isopropylnicotinamide → 5-Chloro-n-(1-methylethyl)-6-[4-(4-methyl-2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide

HRID 2414330ノート

反応式

HRID 2414330 の反応式
[ClH:1].[CH3:2][CH:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[C:5](=[O:19])[O:4]1.Cl[C:21]1[N:26]=[CH:25][C:24]([C:27]([NH:29][CH:30]([CH3:32])[CH3:31])=[O:28])=[CH:23][CH:22]=1>>[Cl:1][C:22]1[CH:23]=[C:24]([C:27]([NH:29][CH:30]([CH3:32])[CH3:31])=[O:28])[CH:25]=[N:26][C:21]=1[N:16]1[CH2:17][CH2:18][CH:13]([N:6]2[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[CH:3]([CH3:2])[O:4][C:5]2=[O:19])[CH2:14][CH2:15]1

参加物

3

反応物 2

HCID 8193696-chloro-N-isopropylnicotinamideHCID 226446811-(4-Piperidyl)-4-methyl-3,1-benzoxazin-2-one hydrochloride

生成物 1

HCID 226446375-Chloro-n-(1-methylethyl)-6-[4-(4-methyl-2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide

実験手順

The title compound was prepared from the product of step (ii) (0.36 g) and the product from example 117 step (i) (0.466 g) using the method of example 115 step (ii). Yield 0.112 g

出典と根拠

ORDレコード
ord-372703aa2407456fb403edf33930f71c
出典データセット
uspto-grants-2004_11
特許番号
US06812226B2

反応ノート

読み込み中…