6-chloro-N-isopropylnicotinamide → 5-Chloro-n-(1-methylethyl)-6-[4-(3-oxo-2,3-dihydro-4h-1,4-benzoxazin-4-yl)piperidin-1-yl]pyridine-3-carboxamide
反応式
[ClH:1].[NH:2]1[CH2:7][CH2:6][CH:5]([N:8]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[O:11][CH2:10][C:9]2=[O:18])[CH2:4][CH2:3]1.Cl[C:20]1[N:25]=[CH:24][C:23]([C:26]([NH:28][CH:29]([CH3:31])[CH3:30])=[O:27])=[CH:22][CH:21]=1>>[Cl:1][C:21]1[CH:22]=[C:23]([C:26]([NH:28][CH:29]([CH3:31])[CH3:30])=[O:27])[CH:24]=[N:25][C:20]=1[N:2]1[CH2:3][CH2:4][CH:5]([N:8]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[O:11][CH2:10][C:9]2=[O:18])[CH2:6][CH2:7]1参加物
3
実験手順
The title compound was prepared from 4-piperidin-4-yl-4H-benzo[1,4]oxazin-3-one hydrochloride (WO 9502405) (0.13 g) and the product from example 117 step (i) (0.13 g) according to the method of example 115 step (ii). Yield 0.04 g as a solid.
出典と根拠
- ORDレコード
- ord-5ed5bfd262584790994b37f9ff879995
- 出典データセット
- uspto-grants-2004_11