Veratrole → Methyl 4-(3,4-dimethoxybenzoyl)benzoate

HRID 2414433ノート

反応式

HRID 2414433 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[Cl-].[C:6]([O:17][CH3:18])(=[O:16])[C:7]1[CH:15]=[CH:14][C:10]([C:11]([O-:13])=O)=[CH:9][CH:8]=1.[CH3:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[O:27][CH3:28]>ClCCl>[CH3:19][O:20][C:21]1[CH:26]=[C:25]([CH:24]=[CH:23][C:22]=1[O:27][CH3:28])[C:11]([C:10]1[CH:9]=[CH:8][C:7]([C:6]([O:17][CH3:18])=[O:16])=[CH:15][CH:14]=1)=[O:13]

参加物

5

反応物 3

HCID 7043VeratroleHCID 6451240Aluminum(III) ChlorideHCID 22493623Monomethyl terephthalate chloride

生成物 1

HCID 22645197Methyl 4-(3,4-dimethoxybenzoyl)benzoate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

実験手順

2.1 g (15.72 mmol) of aluminum chloride, a solution of 2.39 g (12.02 mmol) of monomethyl terephthalate chloride dissolved in 2 ml of dichloromethane and 1.2 ml (9.25 mmol) of 1,2-dimethoxybenzene dissolved in 2 ml of dichloromethane were added to 10 ml of dichloromethane, and they were stirred overnight. The reaction solution was poured into 5 g of 1 N hydrochloric acid/ice. After the treatment with chloromethane as the extraction solvent in an ordinary manner, the solvent was evaporated, and the obtained residue was washed with ethyl acetate and dichloromethane to obtain-the title compound.

後処理

  1. customAfter the treatment with chloromethane as the extraction solvent in an ordinary manner, the solvent was evaporated
  2. washthe obtained residue was washed with ethyl acetate and dichloromethane to obtain-the title compound

出典と根拠

ORDレコード
ord-0bfec44d58c34080a9cda13fb3f62a41
出典データセット
uspto-grants-2004_11
特許番号
US06812231B2

反応ノート

読み込み中…