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Sodium hydride → 1-Benzyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinolin-4-ylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-Aminobenzonitrile | HCID 72913 | — |
| 反応物 | 2-(1-Benzyl-pyrrolidin-2-ylideneamino)benzonitrile | HCID 758406 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 生成物 | 1-Benzyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinolin-4-ylamine | HCID 711989 | — |
| 生成物 | HCID 178420813 | HCID 178420813 | — |
反応手順
Pyrroloquinoline compounds were synthesized as follows. The compound 1-benzyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinolin-4-ylamine was prepared from the cyclization of an amidine derivative, 2-(1-benzyl-pyrrolidin-2-ylideneamino)benzonitrile, which was synthesized by condensing an anthranilonitrile and 1-benzyl-2-pyrrolidione. This compound was then reacted with potassium tert-butoxide or sodium hydride and the corresponding alkyl chloride or acyl chloride (FIG. 6).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06815442B2 |
| 出典データセット | uspto-grants-2004_11 |
| ORD ID | ord-a4925147f81146e2b5c9171157dfd38a |
| 出典メモ | uspto-grants-2004_11 |