Hydrochloric Acid → HCID 22643446、化合物
反応式
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([O:19][CH:20]4[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]4)[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:32]>CO>[ClH:32].[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([O:19][CH:20]4[CH2:24][CH2:23][NH:22][CH2:21]4)[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
A solution of thus-obtained t-butyl 3-{[1-(phenylsulfonyl)-1H-indol-4-yl]oxy}-1-pyrrolidinecarboxylate (0.41 g, 0.93 mmol) in methanol and HCl (5.0 ml, 1M in ether) is heated at 60° C. under nitrogen for 2 h and concentrated in vacuo. The residue is treated with ethyl acetate and filtered. The filtercake is dried under vacuum to give the title product as an off white solid, 0.301 g, mp 200-201° C., identified by NMR and mass spectral analyses.
後処理
- concentration