関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-(4-Fluoro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline | HCID 37411 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | tert-Butyl N-(2-bromoethyl)carbamate | HCID 4103526 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 69763736 | HCID 69763736 | — |
反応手順
To a solution of 1-(4-fluorobenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline (example A31, 1.05 g, 3.5 mmol) in THF (40 mL) is added (2-bromo-ethyl)-carbamic acid tert-butyl ester (example B1, 0.94 g, 4.2 mmol) and DIPEA. The reaction mixture is stirred at 70° C. in a sealed flask for 5 days. After cooling to rt, the reaction mixture is evaporated to dryness, and the residue is purified by preparative HPLC to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06815451B2 |
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| 出典データセット | uspto-grants-2004_11 |
|---|
| ORD ID | ord-cf33ce8e019049ccb201b8713b078e9f |
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| 出典メモ | uspto-grants-2004_11 |
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