Dimethylamine → HCID 178482967、化合物

HRID 2415040ノート

反応式

HRID 2415040 の反応式
O.[NH2:2][C:3]1[N:8]=[C:7](Cl)[CH:6]=[C:5]([OH:10])[N:4]=1.[CH3:11][NH:12][CH3:13]>C(O)C>[NH2:2][C:3]1[N:8]=[C:7]([N:12]([CH3:13])[CH3:11])[CH:6]=[C:5]([OH:10])[N:4]=1

参加物

4

反応物 2

HCID 674DimethylamineHCID 178508975HCID 178508975、化合物

生成物 1

HCID 178482967HCID 178482967、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Amino-4-chloro-6-hydroxypyrimidine monohydrate (5.0 g) was stirred with 30% dimethylamine in ethanol (180 mL) at 100° C. in an autoclave for 16 h. The crystalline product was filtered, washed with water, acetone, ether and dried in vacuo to afford 2-amino-4-dimethylamino-6-hydroxypyrimidine, not melting under 300° C. Yield, 4.3 g (81%). For C6H10N4O (154.17) calculated 46.34% C, 6.54% H, 36.34% N; found 46.38% C, 6.65% H, 36.68% N. 1H-NMR (CD3SOCD3): 2.89 s, 6H (N—CH3); 4.51 s, 1H (H-5); 6.18 brs, 2H (NH2); 9.75 brs, 1H (OH).

後処理

  1. filtrationThe crystalline product was filtered
  2. washwashed with water, acetone, ether
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-630ad0f4650a45cba01a529d8d0727b5
出典データセット
uspto-grants-2004_11
特許番号
US06818633B2

反応ノート

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