[Cl:1][C:2]1[C:3]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([O:19][CH3:20])[CH:13]=2)=[N:4][C:5]([CH3:9])=[N:6][C:7]=1[CH3:8].Cl[C:22]1[CH:23]=[CH:24][C:25]2[N:26]([C:28]([N+:31]([O-:33])=[O:32])=[CH:29][N:30]=2)[N:27]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:1][C:2]1[C:3]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][C:22]3[CH:23]=[CH:24][C:25]4[N:26]([C:28]([N+:31]([O-:33])=[O:32])=[CH:29][N:30]=4)[N:27]=3)=[C:14]([O:19][CH3:20])[CH:13]=2)=[N:4][C:5]([CH3:9])=[N:6][C:7]=1[CH3:8]In analogy to the method described in example 1, 1.25 g (4.25 mmol) of 4-[(5-chloro-2,6-dimethyl-pyrimidin-4-ylamino)methyl]-2-methoxyphenol (from example B3), 0.86 g (4.25 mmol) of 6-chloro-3-nitroimidazo[1,2-b]pyridazine and 3.0 g (21.25 mmol) of potassium carbonate are reacted in 25 ml of dimethylformamide. After chromatography on silica gel (mobile phase: gradient toluene/dioxane 5:1 to 2:1) and crystallization from methylene chloride/methanol, 1.24 g (64%) of the title compound are isolated as a pale beige solid. m.p.: 229-232° C.
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