Hydrochloric Acid → HCID 22640745、化合物
反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[CH:21]=[C:20]([O:22][CH3:23])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1)(C)(C)C.[ClH:25]>ClCCl.O1CCOCC1>[ClH:25].[ClH:25].[CH3:23][O:22][C:20]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=[C:12]([NH:11][CH2:10][CH2:9][CH2:8][NH2:7])[CH:21]=1参加物
5
実験手順
A solution of [3-(4-methoxyquinolin-2-ylamino)propyl]carbamic acid tert-butyl ester (3.10 g, 9.35 mmol) in anhydrous dichloromethane (20 ml) was treated with 4N HCl in 1,4-dioxane (10 ml). It was stirred at ambient temperature for 2 hours then was evaporated under reduced pressure to give N′-(4-methoxyquinolin-2-yl)propane-1,3-diamine dihydrochloride (2.81 g, 99%) as a white solid. [M+H]+ 232.
後処理
- customthen was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-8d16d3f71dd04507b92ee356ac88b29c
- 出典データセット
- uspto-grants-2004_11
- 特許番号
- US06818655B2
反応ノート
読み込み中…