Losartan → Losartan Ang-(1-7) Arginine

HRID 241528

反応式

HRID 241528 の反応式
[CH3:1][CH2:2][C@@H:3]([C@H:5]([NH:26][C:27]([C@@H:29]([NH:38][C:39]([C@@H:41]([NH:45][C:46]([C@@H:48]([NH:56][C:57]([C@@H:59]([NH2:64])[CH2:60][C:61]([OH:63])=[O:62])=[O:58])[CH2:49][CH2:50][CH2:51][N:52]=[C:53]([NH2:55])[NH2:54])=[O:47])[CH:42]([CH3:44])[CH3:43])=[O:40])[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][CH:32]=1)=[O:28])[C:6]([NH:8][C@H:9]([C:16]([N:18]1[C@H:22]([C:23]([OH:25])=[O:24])[CH2:21][CH2:20][CH2:19]1)=[O:17])[CH2:10][C:11]1[NH:15][CH:14]=[N:13][CH:12]=1)=[O:7])[CH3:4].[NH2:65][C@H:66]([C:74]([OH:76])=[O:75])[CH2:67][CH2:68][CH2:69][NH:70][C:71](=[NH:73])[NH2:72].[CH3:77][CH2:78][CH2:79][CH2:80][C:81]1[N:85]([CH2:86][C:87]2[CH:88]=[CH:89][C:90]([C:93]3[CH:94]=[CH:95][CH:96]=[CH:97][C:98]=3[C:99]3[N:103]=[N:102][NH:101][N:100]=3)=[CH:91][CH:92]=2)[C:84]([CH2:104][OH:105])=[C:83]([Cl:106])[N:82]=1>O>[CH3:77][CH2:78][CH2:79][CH2:80][C:81]1[N:85]([CH2:86][C:87]2[CH:92]=[CH:91][C:90]([C:93]3[CH:94]=[CH:95][CH:96]=[CH:97][C:98]=3[C:99]3[N:103]=[N:102][NH:101][N:100]=3)=[CH:89][CH:88]=2)[C:84]([CH2:104][OH:105])=[C:83]([Cl:106])[N:82]=1.[CH3:1][CH2:2][C@@H:3]([C@H:5]([NH:26][C:27]([C@@H:29]([NH:38][C:39]([C@@H:41]([NH:45][C:46]([C@@H:48]([NH:56][C:57]([C@@H:59]([NH2:64])[CH2:60][C:61]([OH:63])=[O:62])=[O:58])[CH2:49][CH2:50][CH2:51][N:52]=[C:53]([NH2:55])[NH2:54])=[O:47])[CH:42]([CH3:44])[CH3:43])=[O:40])[CH2:30][C:31]1[CH:32]=[CH:33][C:34]([OH:37])=[CH:35][CH:36]=1)=[O:28])[C:6]([NH:8][C@H:9]([C:16]([N:18]1[C@H:22]([C:23]([OH:25])=[O:24])[CH2:21][CH2:20][CH2:19]1)=[O:17])[CH2:10][C:11]1[NH:15][CH:14]=[N:13][CH:12]=1)=[O:7])[CH3:4].[NH2:65][C@H:66]([C:74]([OH:76])=[O:75])[CH2:67][CH2:68][CH2:69][NH:70][C:71](=[NH:72])[NH2:73]

参加物

5

反応物 3

HCID 3961LosartanHCID 123805Angiotensin-(1-7)2 回HCID 178418600HCID 178418600、化合物3 回

生成物 1

HCID 178441682Losartan Ang-(1-7) Arginine

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

The Ang-(1-7) losartanate compound (PID) was weighed and placed in a beaker to which a few milliliters of Milli-Q water were added. Since this compound is insoluble in water a turbid solution was observed having suspended particles. L-arginine was added to the solution under agitation, at a molar ratio of 4:1:1 (L-arginine:Losartan:Angiotensin-(1-7)), and a total clearing of the solution was observed, which indicated the solubility of the compound after the interaction with L-arginine. The final solution was placed in eppendorf tubes and frozen in liquid nitrogen, being submitted to the lyophilization process for 24 hours. The compound was called PAD and was submitted to physicochemical characterization.

後処理

  1. additionwere added
  2. temperaturefrozen in liquid nitrogen

出典と根拠

ORDレコード
ord-75fe930b28d34ffb8011e18951ae6050
出典データセット
uspto-grants-2014_02
特許番号
US08653031B2

関連ノート

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