3-(Bromomethyl)-2-chloro-6-(trifluoromethyl)pyridine → HCID 22641451、化合物
反応式
[CH3:1][C:2]1[CH:11]=[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][C:6]([OH:17])=[CH:7][CH:8]=2)[N:3]=1.Br[CH2:19][C:20]1[C:21]([Cl:30])=[N:22][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:25]=1>>[Cl:30][C:21]1[C:20]([CH2:19][O:17][C:6]2[CH:5]=[C:4]3[C:9]([C:10]([N:12]4[CH2:16][CH2:15][CH2:14][CH2:13]4)=[CH:11][C:2]([CH3:1])=[N:3]3)=[CH:8][CH:7]=2)=[CH:25][CH:24]=[C:23]([C:26]([F:27])([F:28])[F:29])[N:22]=1参加物
3
実験手順
In analogy to example 6 there was prepared: on reaction of 2-methyl-4-pyrrolidin-1-yl-quinolin-7-ol with 3-bromomethyl-2-chloro-6-trifluoromethyl-pyridine, whereby the product was isolated as free base, 7-(2-chloro-6-trifluoromethyl-pyridin-3-ylmethoxy)-2-methyl-4-pyrrolidin-1-yl-quinoline as a white solid. ISP mass spectrum, m/e: 422.2 (M+1 calculated for C21H19CIF3N3O: 422).
後処理
- customIn analogy to example 6 there was prepared
出典と根拠
- ORDレコード
- ord-c85b4536ffe54b0baa0ce680c95152ee