Benzoic acid, 4-(bromomethyl)-2-ethoxy-, ethyl ester → Ethyl 2-ethoxy-4-(2-ethoxy-2-oxoethyl)benzoate

HRID 2415506ノート

反応式

HRID 2415506 の反応式
Br[CH2:2][C:3]1[CH:13]=[CH:12][C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:5]([O:14][CH2:15][CH3:16])[CH:4]=1>C(O)C>[CH2:15]([O:14][C:5]1[CH:4]=[C:3]([CH2:2][C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:13]=[CH:12][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH3:16]

参加物

3

反応物 1

HCID 10589339Benzoic acid, 4-(bromomethyl)-2-ethoxy-, ethyl ester

生成物 1

HCID 10378914Ethyl 2-ethoxy-4-(2-ethoxy-2-oxoethyl)benzoate収率 177.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

A mixture of ethyl 4-bromomethyl-2-ethoxy-benzoate (4, 1 gm, 3.5 mmol), dichlorobis(1,2,5-triphenylphosphole)-palladium catalyst (0.1 gm), ethyl alcohol (5 ml) was heated to 50° C. with CO for 6-15 hrs. Catalyst was filtered and solvent was removed to yield the product ethyl 3-ethoxy-4-ethoxycarbonyl-phenylacetate (1, 0.87 gm, 3.1 mmol, 88%).

後処理

  1. filtrationCatalyst was filtered
  2. customsolvent was removed

出典と根拠

ORDレコード
ord-4b526443dbd44d89adc4bfb3030ebd95
出典データセット
uspto-grants-2004_11
特許番号
US06818786B2

反応ノート

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