N-(2-bromo-phenyl)-3-ethoxy-acrylamide → 8-Bromo-1,2-dihydroquinolin-2-one

HRID 2415890ノート

反応式

HRID 2415890 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:15])[CH:10]=[CH:11]OCC>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:8][C:9](=[O:15])[CH:10]=[CH:11]2

参加物

3

反応物 1

HCID 68586854N-(2-bromo-phenyl)-3-ethoxy-acrylamide

生成物 1

HCID 109330948-Bromo-1,2-dihydroquinolin-2-one

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

6 g (22.21 mmol) of N-(2-bromo-phenyl)-3-ethoxy-acrylamide are added batchwise to 30 ml of concentrated sulphuric acid (exothermic) and stirred for one hour. The reaction mixture is poured onto ice water and the precipitate formed is filtered off. The product is purified by column chromatography on silica gel (eluant: dichloromethane/ethyl acetate=3:1).

後処理

  1. additionThe reaction mixture is poured onto ice water
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. customThe product is purified by column chromatography on silica gel (eluant: dichloromethane/ethyl acetate=3:1)

出典と根拠

ORDレコード
ord-42055ce2719743f388da10fbe354df72
出典データセット
uspto-grants-2004_11
特許番号
US06821967B2

反応ノート

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