Ammonia → 8-Bromo-2-chloroquinoline

HRID 2415891

反応式

HRID 2415891 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[NH:10][C:9](=O)[CH:8]=[CH:7]2.O.N.P(Cl)(Cl)([Cl:17])=O>>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([Cl:17])[CH:8]=[CH:7]2

参加物

5

反応物 4

HCID 222AmmoniaHCID 962WaterHCID 24813Phosphorus oxychlorideHCID 109330948-Bromo-1,2-dihydroquinolin-2-one

生成物 1

HCID 109557558-Bromo-2-chloroquinoline

実験手順

A suspension of 2.8 g (12.49 mmol) of 8-bromo-1H-quinoline-2-one in 20 ml of phosphorus oxychloride is refluxed for 90 minutes and the reaction mixture is cooled and then added dropwise to 200 ml of water. The aqueous solution is made basic with concentrated ammonia solution, the precipitate formed is filtered off and washed with water.

後処理

  1. temperatureis refluxed for 90 minutes
  2. temperaturethe reaction mixture is cooled
  3. customthe precipitate formed
  4. filtrationis filtered off
  5. washwashed with water

出典と根拠

ORDレコード
ord-5a0e0f02466448bca837c883e86815a5
出典データセット
uspto-grants-2004_11
特許番号
US06821967B2

関連ノート

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