Hydrochloric Acid → HCID 69733595、化合物

HRID 2416426ノート

反応式

HRID 2416426 の反応式
C([O:4][C@@H:5]([CH3:32])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:15](=[O:16])[C:14]2[C:17](=[O:29])[CH:18]=[C:19]([CH3:28])[N:20]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:13]=2[N:12]([CH3:30])[C:11]1=[O:31])(=O)C.Cl.C(=O)(O)[O-].[Na+]>CO>[CH2:21]([N:20]1[C:13]2[N:12]([CH3:30])[C:11](=[O:31])[N:10]([CH2:9][CH2:8][CH2:7][CH2:6][C@@H:5]([OH:4])[CH3:32])[C:15](=[O:16])[C:14]=2[C:17](=[O:29])[CH:18]=[C:19]1[CH3:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 69732875HCID 69732875、化合物

生成物 1

HCID 69733595HCID 69733595、化合物収率 89%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of (S)-3-(5-acetoxyhexyl)-8-benzyl-1,7-dimethylpyrido[2,3-d]pyrimidine-2,4,5(1H,3H,8H)-trione (1.2 g, 2.7 mmol), methanol (10 ml) and 37% aqueous hydrochloric acid (2 ml) was stirred at room temperature for 18 hours. The mixture was treated with saturated aqueous sodium bicarbonate solution (20 ml). The solid was filtered, rinsed with water, and air dried to afford (S)-8-benzyl-1,7-dimethyl-3-(5-hydroxyhexyl)pyrido[2,3-d]pyrimidine-2,4,5(1H,3H,8H)-trione (850 mg, 89% yield) as a white fluffy powder. 1H NMR (300 MHz, CDCl3) δ 1.17 (d, 3H), 1.38-1.6 (m, 6H), 2.47 (s, 3H), 3.63 (s, 3H), 3.78 (m, 1H), 4.05 (t, 2H), 5.28 (s, 2H), 6.56 (s, 1H), 7.23-7.57 (m, 5H).

後処理

  1. filtrationThe solid was filtered
  2. washrinsed with water, and air
  3. customdried

出典と根拠

ORDレコード
ord-bedec1ccbe9d46d1914d787115da6a9f
出典データセット
uspto-grants-2004_11
特許番号
US06825180B2

反応ノート

読み込み中…