Triethylamine → HCID 22632759、化合物

HRID 2416621ノート

反応式

HRID 2416621 の反応式
[C:1]1([C:7]2[O:8][CH:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:10](=[O:13])[NH:11][N:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20]1(OB(O)O)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(N(CC)CC)C>C(Cl)Cl.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[C:1]1([C:7]2[O:8][CH:9]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:10](=[O:13])[N:11]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 3

HCID 8471TriethylamineHCID 78412Phenyl dihydrogen orthoborateHCID 22632809HCID 22632809、化合物

生成物 1

HCID 22632759HCID 22632759、化合物収率 37%

試薬・触媒・溶媒 2

HCID 8895Cupric acetate触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of 2,6-diphenyl-4H-1,3,4-oxadiazine-5-one (0.1 g), phenyl boric acid (0.13 g), copper acetate (0.18 g) and triethylamine (0.12 g) was stirred vigorously in methylene chloride (15 ml) overnight at room temperature. The reaction in solution was purified directly by silica gel chromatography (ethyl acetate/hexane, 1:2), to give the title compound as a white powder (0.048 g, 37%).

後処理

  1. customThe reaction in solution
  2. customwas purified directly by silica gel chromatography (ethyl acetate/hexane, 1:2)

出典と根拠

ORDレコード
ord-ad222466ce714db6908d9372caae192d
出典データセット
uspto-grants-2004_11
特許番号
US06825192B1

反応ノート

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