1,4-Dioxane hydrochloride → Ethyl 2-(6-(methylamino)pyridin-2-yl)acetate

HRID 2416693ノート

反応式

HRID 2416693 の反応式
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][CH2:13]C(OC(C)(C)C)=O)[N:7]=1)[CH3:2].Cl.O1CCOCC1>>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][CH3:13])[N:7]=1)[CH3:2]

参加物

3

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22496030Ethyl-6-[(tert-butoxycarbonyl)methylamino]-2-pyridylacetate

生成物 1

HCID 22507068Ethyl 2-(6-(methylamino)pyridin-2-yl)acetate

実験手順

A solution of ethyl-6-[(tert-butoxycarbonyl)methylamino]-2-pyridylacetate (0.6 g, 2 mmol) and 4 M HCl/dioxane (5 mL, 20 mmol) was stirred at RT overnight, then was concentrated. Reconcentration from toluene gave the title compound as white solid: MS (ES) m/e 195 (M+H)+.

後処理

  1. concentrationwas concentrated

出典と根拠

ORDレコード
ord-7ad9f5869d8f44f5b20c20eadcc6b005
出典データセット
uspto-grants-2004_11
特許番号
US06825188B2

反応ノート

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