Bromine → Ethyl 2-bromo-4-methyl-3-oxopentanoate
反応式
C([O-])(=O)C.[Na+].[CH2:6]([O:8][C:9](=[O:16])[CH2:10][C:11](=[O:15])[CH:12]([CH3:14])[CH3:13])[CH3:7].[Br:17]Br>C(O)(=O)C>[Br:17][CH:10]([C:11](=[O:15])[CH:12]([CH3:13])[CH3:14])[C:9]([O:8][CH2:6][CH3:7])=[O:16]参加物
5
反応条件
- 温度
- 10 °C
実験手順
To a suspension of sodium acetate (1.9 g) in glacial acetic acid (15 ml) was added 4-methyl-3-oxo-pentanoic acid ethyl ester (2 g) and the reaction mixture cooled to 10° C. Bromine (0.7 ml) was then added dropwise. The resulting solution was allowed to warm to room temperature and stirred for 1 h. The reaction was complete (by TLC) and was concentrated in vacuum affording 3.8 g crude ethyl product which was used directly in the next synthetic step.
後処理
- temperatureto warm to room temperature
- concentrationwas concentrated in vacuum
- customaffording 3.8 g crude ethyl product which
出典と根拠
- ORDレコード
- ord-99684f208e914c6eb1a480b128c8d64c
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08653075B2
反応ノート
読み込み中…