Sodium Cyanide → Ethyl 4-(cyanomethyl)-1H-pyrrole-2-carboxylate

HRID 241715ノート

反応式

HRID 241715 の反応式
[I-].[CH2:2]([O:4][C:5]([C:7]1[NH:11][CH:10]=[C:9]([CH2:12][N+](C)(C)C)[CH:8]=1)=[O:6])[CH3:3].[C-:17]#[N:18].[Na+]>C(O)C>[C:17]([CH2:12][C:9]1[CH:8]=[C:7]([C:5]([O:4][CH2:2][CH3:3])=[O:6])[NH:11][CH:10]=1)#[N:18]

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 86662429[5-(Ethoxycarbonyl)-1H-pyrrol-3-yl]-N,N,N-trimethyl-methanaminium iodide

生成物 1

HCID 66636709Ethyl 4-(cyanomethyl)-1H-pyrrole-2-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of the product obtained in Step E and sodium cyanide (0.225 g) in ethanol is heated at reflux for 72 hours. After evaporation to dryness, the residue is taken up in a mixture of CH2Cl2/water. The aqueous phase is extracted three times with CH2Cl2. The organic phases are combined. The organic phase is dried over magnesium sulphate, filtered and evaporated to dryness to yield the title product which is used directly in the next Step.

後処理

  1. temperatureat reflux for 72 hours
  2. customAfter evaporation to dryness
  3. additionthe residue is taken up in a mixture of CH2Cl2/water
  4. extractionThe aqueous phase is extracted three times with CH2Cl2
  5. dry with materialThe organic phase is dried over magnesium sulphate
  6. filtrationfiltered
  7. customevaporated to dryness

出典と根拠

ORDレコード
ord-dc555aa76ab04acf8ca88d501acdb85b
出典データセット
uspto-grants-2014_02
特許番号
US08653073B2

反応ノート

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