Ethyl 2-bromo-2-(4-chlorophenyl)acetate → Ethyl(4-chlorophenyl)[(4-hydroxyphenyl)sulfanyl]acetate

反応式

Br[CH:2]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[SH:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=1>>[CH2:6]([O:5][C:3](=[O:4])[CH:2]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)[S:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=1)[CH3:7]

参加物

反応物 2

HCID 228840Ethyl 2-bromo-2-(4-chlorophenyl)acetate

HCID 2401474-Mercaptophenol

生成物 1

HCID 91432097Ethyl(4-chlorophenyl)[(4-hydroxyphenyl)sulfanyl]acetate収率 97%

実験手順

Ethyl(4-chlorophenyl)[(4-hydroxyphenyl)sulfanyl]acetate was prepared according to the general method as outlined in example 1 (step 1), starting from ethyl bromo(4-chlorophenyl)acetate (16.5 g, 59.6 mmol) and 4-mercaptophenol (7.5 g, 59.6 mmol); 18.8 g white solid. mp: 63° C.; Yield 97%; MS: 321.3 (M−H)−

出典と根拠

ORDレコード: ord-66f87649ff7a4385a98b78b68f10c182
出典データセット: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06825354B2

反応ノート

読み込み中…

参加物