Lithium hydroxide, monohydrate → 4-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid

HRID 2417391ノート

反応式

HRID 2417391 の反応式
C[O:2][C:3](=[O:40])[C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[C:15]([OH:17])[C:14]([O:18][CH3:19])=[CH:13][C:12]=2[CH:20]2[CH:29]3[CH2:30][C:31]4[C:36]([CH:28]3[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:37](=[NH:39])[NH2:38])[CH:26]=3)[NH:21]2)=[CH:35][CH:34]=[CH:33][CH:32]=4)=[CH:6][CH:5]=1.O.[OH-].[Li+]>CO.O>[C:37]([C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[NH:21][CH:20]([C:12]1[CH:13]=[C:14]([O:18][CH3:19])[C:15]([OH:17])=[CH:16][C:11]=1[O:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:40])=[O:2])=[CH:9][CH:8]=1)[CH:29]1[CH2:30][C:31]3[C:36]([CH:28]21)=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[NH:38])[NH2:39]

参加物

5

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 698950294-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid methyl ester

生成物 1

HCID 226332754-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

The mixture of 4-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid methyl ester (54 mg, 0.1 mmol) and lithium hydroxide monohydrate (21 mg, 0.5 mmol) in 2.5 mL of MeOH and 1.5 mL of H2O was stirred at room temperature overnight. The desired product 4-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid was purified using reverse phase HPLC. Mass spectrum 521 (M+1).

後処理

  1. customThe desired product 4-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid was purified

出典と根拠

ORDレコード
ord-b06fef9a8e9e4e54b6721d44ebea1c22
出典データセット
uspto-grants-2004_11
特許番号
US06825208B2

反応ノート

読み込み中…