Acetic Acid → Methyl 4-[((4-chlorobenzoyl)ethoxycarbonylmethylamino)methyl]-3-[4-(1-pyrrolidinecarbonyl)benzylamino]-benzoate

HRID 2417477ノート

反応式

HRID 2417477 の反応式
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([CH2:8][CH2:9][O:10][C:11]([CH2:13][NH:14][CH2:15][C:16]2[CH:25]=[CH:24][C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][C:17]=2[NH2:26])=[O:12])=[O:7])=[CH:4][CH:3]=1.[N:29]1([C:34]([C:36]2[CH:43]=[CH:42][C:39]([CH:40]=O)=[CH:38][CH:37]=2)=[O:35])[CH2:33][CH2:32][CH2:31][CH2:30]1.C(O)(=O)C.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([CH2:8][CH2:9][O:10][C:11]([CH2:13][NH:14][CH2:15][C:16]2[CH:25]=[CH:24][C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][C:17]=2[NH:26][CH2:40][C:39]2[CH:38]=[CH:37][C:36]([C:34]([N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)=[O:35])=[CH:43][CH:42]=2)=[O:12])=[O:7])=[CH:27][CH:28]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 5049666Sodium triacetoxyborohydrideHCID 127880444-(Pyrrolidine-1-carbonyl)benzaldehydeHCID 69893404Methyl 4-[((4-chlorobenzoyl)ethoxycarbonylmethylamino)methyl]-3-aminobenzoate

生成物 1

HCID 69892571Methyl 4-[((4-chlorobenzoyl)ethoxycarbonylmethylamino)methyl]-3-[4-(1-pyrrolidinecarbonyl)benzylamino]-benzoate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

120 mg (0.30 mmol) of methyl 4-[((4-chlorobenzoyl)ethoxycarbonylmethylamino)methyl]-3-aminobenzoate and 66 mg (0.33 mmol) of 4-(1-pyrrolidinecarbonyl)benzaldehyde were dissolved in 10 ml of dichloromethane. 0.034 ml (0.6 mmol) of acetic acid was added to the solution, and they were stirred at room temperature for 30 minutes. 158 mg (0.75 mmol) of sodium triacetoxyborohydride was added to the obtained mixture, and they were stirred at room temperature overnight. After the treatment with dichloromethane as the extracting solvent by an ordinary method, the obtained crude product was purified by the silica gel column chromatography to obtain the title compound

後処理

  1. stirringwere stirred at room temperature overnight
  2. customwas purified by the silica gel column chromatography

出典と根拠

ORDレコード
ord-38fca2f32eff4eb3a0fc520809222b2e
出典データセット
uspto-grants-2004_11
特許番号
US06825191B2

反応ノート

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