Ethanol → HCID 22632585、化合物

HRID 2417478ノート

反応式

HRID 2417478 の反応式
[Cl:1][C:2]1[CH:38]=[CH:37][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([C:19]([OH:21])=[O:20])=[CH:18][C:12]=3[N:11]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]([N:31]4[CH2:35][CH2:34][CH2:33][CH2:32]4)=[O:30])=[CH:25][CH:24]=3)[C:10](=[O:36])[CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[CH2:39](O)[CH3:40].C(N(CC)CC)C>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([C:19]([O:21][CH2:39][CH3:40])=[O:20])=[CH:18][C:12]=3[N:11]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]([N:31]4[CH2:32][CH2:33][CH2:34][CH2:35]4)=[O:30])=[CH:25][CH:24]=3)[C:10](=[O:36])[CH2:9]2)=[O:7])=[CH:37][CH:38]=1

参加物

5

反応物 3

HCID 702EthanolHCID 8471TriethylamineHCID 22632665HCID 22632665、化合物

生成物 1

HCID 22632585HCID 22632585、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

5 mg (0.009 mmol) of 4-(4-chlorobenzoyl)-2-oxo-1-[4-(1-pyrrolidinecarbonyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]-diazepine-8-carboxylic acid was dissolved in 5 ml of dichloromethane. 0.001 ml (0.018 mmol) of ethanol, 2 mg (0.011 mmol) of 2-chloro-1,3-dimethylimidazonium chloride and 0.003 ml (0.018 mmol) of triethylamine were added to the obtained solution, and they were stirred overnight. The solvent was evaporated and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

後処理

  1. customThe solvent was evaporated
  2. customthe obtained crude product
  3. additionwas treated in the same manner as in step 3 in Example 1

出典と根拠

ORDレコード
ord-ba79341662eb47868c4d5d17b8b7318e
出典データセット
uspto-grants-2004_11
特許番号
US06825191B2

反応ノート

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