Triethylamine → HCID 22632535、化合物
反応式
[Cl:1][C:2]1[CH:40]=[CH:39][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:18][C:12]=3[N:11]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([C:31]([N:33]4[CH2:37][CH:36]=[CH:35][CH2:34]4)=[O:32])=[CH:27][CH:26]=3)[C:10](=[O:38])[CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[CH2:41](N(CC)CC)[CH3:42]>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([CH2:19][CH2:20][C:21]([O:23][CH2:41][CH3:42])=[O:22])=[CH:18][C:12]=3[N:11]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([C:31]([N:33]4[CH2:37][CH:36]=[CH:35][CH2:34]4)=[O:32])=[CH:27][CH:26]=3)[C:10](=[O:38])[CH2:9]2)=[O:7])=[CH:39][CH:40]=1参加物
4
実験手順
10 mg (0.018 mmol) of 3[4-(4-chlorobenzoyl)-2-oxo-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]-diazepin-8-propionic acid was dissolved in 2 ml of dichloro-methane. 4 mg (0.02 1 mmol) of 2-chloro-1,3-dimethylimidazonium chloride and 0.005 nil (0.036 mmol) of triethylamine were added to the obtained solution, and they were stirred overnight. The solvent was evaporated and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.