Sodium Bicarbonate → Ethyl (5-methyl-2-nitrobenzyl)aminoacetate

HRID 2417501ノート

反応式

HRID 2417501 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH:9]=1)[CH2:7]Cl.Cl.[CH2:14]([O:16][C:17](=[O:20])[CH2:18][NH2:19])[CH3:15].C(=O)([O-])O.[Na+]>C(O)C>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH:9]=1)[CH2:7][NH:19][CH2:18][C:17]([O:16][CH2:14][CH3:15])=[O:20]

参加物

5

反応物 3

HCID 516892Sodium BicarbonateHCID 2723640Glycine ethyl ester, hydrochlorideHCID 2724031alpha-Chloro-5-methyl-2-nitrotoluene

生成物 1

HCID 86217985Ethyl (5-methyl-2-nitrobenzyl)aminoacetate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

5.0 g (27 mmol) of 5-methyl-2-nitrobenzyl chloride was dissolved in 100 ml of ethanol. 7.5 g (54 mmol) of glycine ethyl ester hydrochloride and 6.8 g (81 mmol) of sodium hydrogencarbonate were added to the obtained solution, and they were stirred at 70° C. for 6 hours. The solvent was evaporated. After the extraction with ethyl acetate, the extract was washed with 1 N hydrochloric acid. The obtained aqueous layer was made basic with 1 N sodium hydroxide. After the extraction with ethyl acetate, the obtained organic layer was washed with saturated aqueous sodium chloride solution and then dried. The solvent was evaporated to obtain the title compound.

後処理

  1. customThe solvent was evaporated
  2. extractionAfter the extraction with ethyl acetate
  3. washthe extract was washed with 1 N hydrochloric acid
  4. extractionAfter the extraction with ethyl acetate
  5. washthe obtained organic layer was washed with saturated aqueous sodium chloride solution
  6. customdried
  7. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-cca4db19afb44e3eb28baac5f8cab456
出典データセット
uspto-grants-2004_11
特許番号
US06825191B2

反応ノート

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