Acetyl chloride → 5-(2-Chloroacetyl)-6-fluoroindolin-2-one

HRID 241751

反応式

HRID 241751 の反応式
[Cl-:1].[Al+3].[Cl-].[Cl-].[F:5][C:6]1[CH:14]=[C:13]2[C:9]([CH2:10][C:11](=[O:15])[NH:12]2)=[CH:8][CH:7]=1.[C:16](Cl)(=[O:18])[CH3:17]>C(Cl)Cl>[Cl:1][CH2:17][C:16]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:6]=1[F:5])[NH:12][C:11](=[O:15])[CH2:10]2)=[O:18]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 37310136-fluoro-2,3-dihydro-1H-indol-2-oneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 106093595-(2-Chloroacetyl)-6-fluoroindolin-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
50 °C

実験手順

20 mL of DCM are added dropwise under nitrogen to aluminium chloride (31.1 mmol) at 0-5° C. 6-Fluoroindolin-2-one (5.18 mmol) and acetyl chloride (6.73 mmol) are added to the mixture. The reaction mixture is heated at 50° C. overnight. The reaction mixture is cooled to ambient temperature and then poured into an ice bath, and the suspension obtained is filtered and then washed with cold water to yield the title product.

後処理

  1. temperatureThe reaction mixture is cooled to ambient temperature
  2. additionpoured into an ice bath
  3. customthe suspension obtained
  4. filtrationis filtered
  5. washwashed with cold water

出典と根拠

ORDレコード
ord-d78c29d352cb4bba84c7425fa3357d2b
出典データセット
uspto-grants-2014_02
特許番号
US08653073B2

関連ノート

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