4-(4-chlorobenzoyl)-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-9-methoxy-1,3,4,5-tetrahydrobenzo[e][1,4]-diazepin-2-on → 4-(4-chlorobenzoyl)-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-9-hydroxy-1,3,4,5-tetrahydrobenzo[e][1,4]-diazepin-2-on

HRID 2417529ノート

反応式

HRID 2417529 の反応式
[Cl:1][C:2]1[CH:37]=[CH:36][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][CH:17]=[C:18]([O:19]C)[C:12]=3[N:11]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([N:30]4[CH2:34][CH:33]=[CH:32][CH2:31]4)=[O:29])=[CH:24][CH:23]=3)[C:10](=[O:35])[CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[Br-].[Br-].[Br-].B>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][CH:17]=[C:18]([OH:19])[C:12]=3[N:11]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([N:30]4[CH2:31][CH:32]=[CH:33][CH2:34]4)=[O:29])=[CH:24][CH:23]=3)[C:10](=[O:35])[CH2:9]2)=[O:7])=[CH:36][CH:37]=1

参加物

4

反応物 2

HCID 226325794-(4-chlorobenzoyl)-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-9-methoxy-1,3,4,5-tetrahydrobenzo[e][1,4]-diazepin-2-onHCID 178419136HCID 178419136、化合物

生成物 1

HCID 226326994-(4-chlorobenzoyl)-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-9-hydroxy-1,3,4,5-tetrahydrobenzo[e][1,4]-diazepin-2-on

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

7 mg (0.014 mmol) of 4-(4-chlorobenzoyl)-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-9-methoxy-1,3,4,5-tetrahydrobenzo[e][1,4]-diazepin-2-on was dissolved in 10 ml of dichloromethane. 1.0 ml of borane tribromide was added to the obtained solution, and they were stirred at room temperature overnight. After the treatment with dichloromethane as the extracting solvent by an ordinary method, the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

後処理

  1. additionwas treated in the same manner as in step 3 in Example 1

出典と根拠

ORDレコード
ord-43cc07ae8a084fad9fce0ff253601cf1
出典データセット
uspto-grants-2004_11
特許番号
US06825191B2

反応ノート

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