Phosphorus oxychloride → 6-Chloro-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

HRID 2417592

反応式

HRID 2417592 の反応式
P(Cl)(Cl)([Cl:3])=O.[CH:6]([N:9]1[C:16](=[O:17])[CH2:15][C:13](=O)[NH:12][C:10]1=[O:11])([CH3:8])[CH3:7]>O>[CH:6]([N:9]1[C:16](=[O:17])[CH:15]=[C:13]([Cl:3])[NH:12][C:10]1=[O:11])([CH3:8])[CH3:7]

参加物

4

反応物 2

HCID 24813Phosphorus oxychlorideHCID 2319626-Hydroxy-3-(propan-2-yl)pyrimidine-2,4(3H,5H)-dione

生成物 1

HCID 8201076-Chloro-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

350 ml of phosphorus oxychloride containing 15 ml of water are slowly run into 75 g (0.44 mole) of 1-isopropyl barbituric acid. After the violent exothermic reaction has abated, the reaction mixture is refluxed for 1 hour. The excess POCl3 is removed by evaporation in vacuo and the oily residue is poured onto ice, giving a precipitate which is filtered, washed with ice water and dried. 55 g of yellowish crystals are thus obtained.

後処理

  1. customAfter the violent exothermic reaction
  2. temperaturethe reaction mixture is refluxed for 1 hour
  3. customThe excess POCl3 is removed by evaporation in vacuo
  4. additionthe oily residue is poured onto ice
  5. customgiving a precipitate which
  6. filtrationis filtered
  7. washwashed with ice water
  8. customdried

出典と根拠

ORDレコード
ord-3be8541be9a24fd9ba9d828230fffa95
出典データセット
uspto-grants-1984_09
特許番号
US04469698

関連ノート

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