Ammonium Hydroxide → HCID 13338422、化合物

HRID 2417663ノート

反応式

HRID 2417663 の反応式
Cl[C:2]1[C:3]2[N:11]([CH3:12])[N:10]=[C:9]([CH3:13])[C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.[NH2:14][CH:15]([CH2:18][CH3:19])[CH2:16][OH:17].[OH-].[NH4+]>C1(C)C=CC=CC=1>[CH3:12][N:11]1[C:3]2[C:2]([NH:14][CH:15]([CH2:18][CH3:19])[CH2:16][OH:17])=[N:7][C:6]([CH3:8])=[N:5][C:4]=2[C:9]([CH3:13])=[N:10]1

参加物

5

反応物 3

HCID 14923Ammonium HydroxideHCID 221292-Amino-1-butanolHCID 133384077-Chloro-1,3,5-trimethyl-1H-pyrazolo[4,3-d]pyrimidine

生成物 1

HCID 13338422HCID 13338422、化合物収率 30.1%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 8 g (0.04 mol) of 7-chloro-1,3,5-trimethyl-1H-pyrazolo[4,3-d]pyrimidine (Ex. 3) and 9 g (0.1 mol) of 2-amino-1-butanol in 75 ml of toluene is heated on the steam bath four hours. The warm solution is shaken with 100 ml of 4N ammonium hydroxide. The aqueous extract is concentrated in vacuo to give 3 g of 2-[1,3,5-trimethyl-1-H-pyrazolo[4,3-d]pyrimidin-7-yl]amino-1-butanol, mp 165°-168° C. Another 2.2 g of product is obtained by concentrating the toluene solution.

後処理

  1. temperatureis heated on the steam bath four hours
  2. extractionThe aqueous extract
  3. concentrationis concentrated in vacuo

出典と根拠

ORDレコード
ord-57062a4cfad54e8f8747450cc0ca1c5c
出典データセット
uspto-grants-1984_09
特許番号
US04469868

反応ノート

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