Ammonium Hydroxide → 1H-Pyrazole-5-carboxamide, 1-ethyl-3-methyl-4-nitro-
反応式
[CH2:1]([N:3]1[C:7]([C:8](Cl)=[O:9])=[C:6]([N+:11]([O-:13])=[O:12])[C:5]([CH3:14])=[N:4]1)[CH3:2].[OH-].[NH4+:16]>CC(C)=O>[CH2:1]([N:3]1[C:7]([C:8]([NH2:16])=[O:9])=[C:6]([N+:11]([O-:13])=[O:12])[C:5]([CH3:14])=[N:4]1)[CH3:2]参加物
4
実験手順
A solution of 108 g (0.05 mol) of 1-ethyl-3-methyl-4-nitro-pyrazole-5-carbonyl chloride [J. Med. Chem. 16 1346 (1973)] in 100 ml of acetone is added at a fast droprate to 450 ml cold concentrated ammonium hydroxide with stirring. After one hour, the mixture is filtered; the product is washed with water to give 94 g (95%) of 1-ethyl-3-methyl-4-nitropyrazole-5-carboxamide, mp 175°-177° C.
後処理
- filtrationthe mixture is filtered
- washthe product is washed with water
出典と根拠
- ORDレコード
- ord-dd066804421849a180c9e33504d163a0
- 出典データセット
- uspto-grants-1984_09
- 特許番号
- US04469868
反応ノート
読み込み中…