8-Isobutyryloxy-5-methyl-6-oxo-5,6-dihydro-pyrido[2,3-b]pyrazine-7-carboxylic acid methyl ester → 8-hydroxy-5-methyl-7-(3-methyl-1,2,4-oxadiazol-5-yl)-5H-pyrido[2,3-b]pyrazin-6-one
反応式
CO[C:3]([C:5]1[C:14](=[O:15])[N:13]([CH3:16])[C:8]2=[N:9][CH:10]=[CH:11][N:12]=[C:7]2[C:6]=1[O:17]C(=O)C(C)C)=[O:4].O[NH:24][C:25](=[NH:27])[CH3:26]>C1(C)C=CC=CC=1>[OH:17][C:6]1[C:7]2[C:8](=[N:9][CH:10]=[CH:11][N:12]=2)[N:13]([CH3:16])[C:14](=[O:15])[C:5]=1[C:3]1[O:4][N:27]=[C:25]([CH3:26])[N:24]=1参加物
4
実験手順
To a solution of 8-isobutyryloxy-5-methyl-6-oxo-5,6-dihydro-pyrido[2,3-b]pyrazine-7-carboxylic acid methyl ester (Example 7.3) (0.10 g) in toluene (4 ml) was added N-hydroxy-acetamidine (0.025 g). The reaction mixture was heated to reflux for 16 hours. The reaction mixture was cooled to ambient temperature and the solid was isolated by filtration and dried to give Compound No. B5 of Table 5 (0.050 g).